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Her No. 1: "With enough care and effort you can grow your own Barack-oli," she said while holding up a green "head of baroccoli" with her husband's face etched into its green, veggie-looking surface.
Mrs. Obama's list was related to her new book, "American Grown: The Story of the White House Kitchen Garden and Gardens Across America."
The first lady last appeared on the Letterman show in March. She has been making the rounds of other talk shows in recent weeks to promote her book.
Mrs. Obama's turn in the spotlight comes as President Obama's campaign seeks to use his wife's popularity to help him get re-elected.
The full list of Mrs. Obama's "fun facts":
No. 10: Gardening was invented in 1822 by Albert Gardener.
No. 9: Plant avocadoes, tomatoes, onions and cilantro together and grow a guacamole tree.
No. 8: Eggplants were originally cultivated for use as doorstops.
No. 7: In his lifetime, the average American will eat half a radish.
No. 6: The largest zucchini ever grown contained a Starbucks.
No. 5: Later this year the Supreme Court will finally rule on "tomato" vs. "tomahto."
No. 4: If you have an actual green thumb, it might be scurvy.
No. 3: Lettuce is 96 percent water and 4 percent lettuce.
No. 2: The White House tool shed contains shovels, trowels and Weed Whacker One.
No. 1: "With enough care and effort you can grow your own Barack-oli."
