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Posted on Mon. Aug. 11, 2014 - 12:01 am EDT

Melanoma strikes people of all skin colors

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Betty Jordan always regarded melanoma, the deadliest form of skin cancer, as a white person's disease. “Whenever I heard the word, my mind would automatically think: 'Caucasian,' ” she says. “It was something I never worried about.”

So she was shocked five years ago to learn that the quarter-size dark spot on her left foot was acral lentiginous melanoma, an aggressive cancer that disproportionately afflicts blacks and other dark-skinned people. “I never paid any attention to it until a friend urged me to see a doctor,” she says. “The area was hard to see, and it never occurred to me to get serious about it.”

Fortunately, it was caught early and removed. The prognosis is excellent for Jordan, 69, a retired computer network engineer who lives in Temple Hills, Maryland.

But this is not typically the case for dark-skinned people who develop ALM or other skin cancers. Because they often assume they are not at risk, their cancers tend to be diagnosed at a more advanced stage, and patients are likely to face a bleaker outcome.

“It's true that the vast majority of melanomas occur in fair-skinned people, but it's important to know that dark-skinned people can get skin cancer, too,” says Maral Skelsey, a surgeon and skin cancer specialist who heads the Georgetown University Medical Center's dermatologic surgery center. “They often are dismissed by their general physicians in terms of risk. I hear it so often: 'No one told me I could get skin cancer.' ”

Melanoma rates among all Americans have been increasing for the past 30 years, probably due to failure to take sufficient protective measures against ultraviolet ray exposure and to increasing use of tanning booths.

Melanoma accounts for fewer than 2 percent of skin cancer cases, but it kills more frequently than the others. In 2014, an estimated 76,100 new cases of melanoma will be diagnosed, with about 9,710 deaths, according to the American Cancer Society.

To be sure, melanoma is many times more common in whites (1 in 50) than in blacks (1 in 1,000) or Hispanics (1 in 200). But the danger for affected people of color is greater: The five-year survival rate for blacks is 73 percent, compared with 91 percent for Caucasians, according to the American Academy of Dermatology.

That difference is probably due to later diagnosis and treatment: The initial melanoma diagnosis is not made until the disease is at an advanced stage for an estimated 52 percent of non-Hispanic blacks and 26 percent of Hispanics, compared with 6 percent of non-Hispanic white patients, according to the Skin Cancer Foundation, a public education and research organization.

ALM, while rare overall, primarily strikes people of color – blacks, Asians, Pacific Islanders and Hispanics – and it can be lethal.

The disease is most often found on the palms, nail beds and soles of the feet. These are areas of the body that have less pigment and receive less exposure to the sun; they also are locations people are most likely to ignore.

Reggae musician Bob Marley died in 1981 at age 36 from ALM, initially thought to have been a soccer bruise under his toenail.

“This is a deadly form of skin cancer, which disproportionately afflicts blacks and can behave more aggressively,” says Suraj Venna, director of the Melanoma and Cutaneous Oncology Center in the Washington Cancer Institute at MedStar Washington Hospital Center. “The way to combat this is to educate people from these communities, as well as their health care providers.”

Experts don't know why ALM overwhelmingly affects people of color or why it usually shows up in less-pigmented areas of their bodies.

“There likely is some interplay in biology, ethnicity and the environment,” Venna says. “Maybe there is some protein or gene we are not seeing in the white population. Pigment does protect them, which probably explains why they don't have the same incidence of melanoma on their backs or legs. … The field definitely needs more studies on genetics and ethnic variation, especially to explain the poorer outcomes in African-Americans.”

Dermatology experts stress that dark-skinned people should never be complacent about their risk of skin cancer. These experts recommend regular full-body examinations for them, just as for fair-skinned individuals, and urge them to be especially vigilant about routinely checking locations where ALM typically develops.

“Your physician shouldn't dismiss you just because you are black if you have any new or changing skin lesions on your body, especially nail changes,” Skelsey says. “If somebody has a wide, dark streak under a nail or on the edge of the skin where it meets the nail, it is very important to have it evaluated, especially if it is something that persists and is wide and solitary. The only way to know for sure is to biopsy the area.”

The only effective treatment for ALM is surgical removal of the cancer, which makes early detection especially important.

As for ALM survivor Betty Jordan, she undergoes a full-body examination every six months and she frequently examines her nails, palms and the soles of her feet. “This was something I never thought about before,” she says. “But I pay close attention now.”

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